Leucine

Leucine

SCHEMBL4551207

CC(C)C[C@H](N)C(=O)O.Nc1ccccc1

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 2/20 0.67
SLC1A3 P43003 4/20 0.53
SLC1A2 P43004 4/20 0.53
ANPEP P15144 1/20 0.53
RNPEP Q9H4A4 1/20 0.53
DNPEP Q9ULA0 1/20 0.53
SLC1A1 P43005 3/20 0.50
GRM2 Q14416 2/20 0.50
GRM3 Q14832 2/20 0.50
LARS1 Q9P2J5 1/20 0.50
ALPI P09923 1/20 0.48
PKM P14618 1/20 0.48
PTGS1 P23219 1/20 0.48
XIAP P98170 1/20 0.48
LTA4H P09960 1/20 0.46
GRIK1 P39086 2/20 0.45
ELANE P08246 1/20 0.45
GRIK2 Q13002 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Leucine SCHEMBL21141614 1.00 SLC7A5 (0.67) SLC7A5SLC1A3SLC1A2ANPEPRNPEP
Leucine SCHEMBL8590001 0.96 SLC7A5 (0.62) SLC7A5SLC1A3SLC1A2ANPEPRNPEP
Naphthalene SCHEMBL8050413 0.87 SLC7A5 (0.69) SLC7A5SLC1A3SLC1A2ANPEPRNPEP
Naphthalene SCHEMBL8050416 0.87 SLC7A5 (0.69) SLC7A5SLC1A3SLC1A2ANPEPRNPEP
Anthraquinone SCHEMBL27983864 0.84 SLC7A5 (0.64) SLC7A5SLC1A3SLC1A2ANPEPRNPEP
Leucine SCHEMBL28833029 0.84 SLC7A5 (0.64) SLC7A5SLC1A3SLC1A2ANPEPRNPEP
Leucine SCHEMBL10633735 0.83 SLC7A5 (0.58) SLC7A5SLC1A3SLC1A2ANPEPRNPEP
Leucine SCHEMBL11847582 0.83 SLC7A5 (0.58) SLC7A5SLC1A3SLC1A2ANPEPRNPEP
Leucine SCHEMBL11847578 0.83 SLC7A5 (0.58) SLC7A5SLC1A3SLC1A2ANPEPRNPEP
Leucine SCHEMBL26687076 0.83 SLC7A5 (0.58) SLC7A5SLC1A3SLC1A2ANPEPRNPEP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7566690-B2 Ace inhibitory peptides from plant materials HER MAJESTY THE QUEEN IN RIGHT OF CANADA AS REPRESENTED BY THE MINISTER OF AGRICULTURE AND AGRI-FOOD CANADA (CA) 2009-07-28 US disclosed
US-20060217318-A1 Ace inhibitory peptides from plant materials HER MAJESTY THE QUEEN IN RIGHT OF CANADA AS REPRESENTED BY THE MINISTER OF AGRICULTURE AND AGRI-FOOD CANADA (CA) 2006-09-28 US disclosed
EP-1575375-A1 ACE INHIBITORY PEPTIDES FROM PLANT MATERIALS Her Majesty The Queen in Right of Canada, as represented by The Minister of Agriculture and Agri-Food Canada (CA) 2005-09-21 EP disclosed
WO-2004057976-A1 ACE INHIBITORY PEPTIDES FROM PLANT MATERIALS HER MAJESTY THE QUEEN IN RIGHT OF CANADA AS REPRESENTED BY THE MINISTER OF AGRICULTURE AND AGRI-FOOD CANADA (CA) 2004-07-15 WO disclosed