Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | SNCA | P37840 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | FABP2 | P12104 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2983981 | 0.90 | MAPT (0.60) | SMN1; SMN2HTTMAPTNAMPTTBXAS1 | |
| SCHEMBL2983375 | 0.87 | NAMPT (0.49) | SMN1; SMN2MAPTNAMPTTBXAS1TBXA2R | |
| SCHEMBL2982849 | 0.82 | GAA (0.55) | SMN1; SMN2HTTMAPTPTGDR2NPC1 | |
| SCHEMBL4078169 | 0.81 | MCHR1 (0.55) | SMN1; SMN2HTTMAPTPTGDR2KMT2A | |
| SCHEMBL2986449 | 0.80 | EPHX2 (0.50) | SMN1; SMN2MAPTPTGDR2MAPK14KMT2A | |
| SCHEMBL2981219 | 0.80 | PPARA (0.52) | SMN1; SMN2HTTMAPTPTGDR2NPC1 | |
| SCHEMBL2983975 | 0.80 | MAPT (0.55) | SMN1; SMN2HTTMAPTNAMPTTBXAS1 | |
| SCHEMBL2981095 | 0.79 | HTT (0.63) | SMN1; SMN2HTTMAPTPTGDR2KMT2A | |
| SCHEMBL2983606 | 0.79 | PPARA (0.49) | SMN1; SMN2HTTMAPTPTGDR2NPC1 | |
| SCHEMBL12970002 | 0.79 | PTGDR2 (0.47) | SMN1; SMN2HTTMAPTPTGDR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057115-A1 | 4-SUBSTITUTED PHENOXYPHENYLACETIC ACID DERIVATIVES | Array Biopharma, Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008024746-A1 | 4-SUBSTITUTED PHENOXYPHENYLACETIC ACID DERIVATIVES | ARRAY BIOPHARMA, INC. (US) | 2008-02-28 | — | — | WO | disclosed |