⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5257989 | 1.00 | — | — | |
| SCHEMBL8072720 | 1.00 | — | — | |
| SCHEMBL7749229 | 0.97 | CHRM2 (0.48) | — | |
| Hydrochloric Acid SCHEMBL20767612 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL20797704 | 0.97 | — | — | |
| SCHEMBL25124368 | 0.97 | CHRM2 (0.48) | — | |
| Hydrochloric Acid SCHEMBL20767606 | 0.97 | — | — | |
| SCHEMBL1246378 | 0.97 | CHRM2 (0.48) | — | |
| SCHEMBL6602399 | 0.97 | CHRM2 (0.48) | — | |
| SCHEMBL18101264 | 0.97 | CHRM2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 494 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9949975-B2 | Inhibitors of beta-secretase | VITAE PHARMACEUTICALS, INC. (US) | 2018-04-24 | — | — | US | claimed |
| US-20170196867-A1 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, INC. (US) | 2017-07-13 | — | — | US | claimed |
| EP-1885349-B1 | Sulphamides for treatment of cancer | MERCK SHARP & DOHME (GB) | 2016-03-09 | — | — | EP | claimed |
| US-8513239-B2 | Chiral cis-imidazolines | HOFFMANN-LA ROCHE INC. (US) | 2013-08-20 | — | — | US | claimed |
| US-20120157494-A1 | ISOINDOLYL COMPOUNDS | HARRIS III RALPH NEW (US) | 2012-06-21 | — | — | US | claimed |
| US-20110263580-A1 | METHOD FOR TREATING ALZHEIMER'S DISEASE AND RELATED CONDITIONS | MERCK SHARP & DOHME CORP. | 2011-10-27 | — | — | US | claimed |
| EP-2375895-A1 | METHOD FOR TREATING ALZHEIMER'S DISEASE AND RELATED CONDITIONS | Merck Sharp & Dohme Corp. (US) | 2011-10-19 | — | — | EP | claimed |
| EP-1392660-B1 | SUBSTITUTED BENZOYLCYCLOHEXENONES AND THEIR USE AS HERBICIDAL AGENTS | BAYER AG (DE) | 2010-08-04 | — | — | EP | claimed |
| WO-2010068564-A1 | METHOD FOR TREATING ALZHEIMER'S DISEASE AND RELATED CONDITIONS | MERCK SHARP & DOHME CORP. (US) | 2010-06-17 | — | — | WO | claimed |
| US-7635664-B2 | Herbicidal substituted benzoylpyrazoles | BAYER CROPSCIENCE AG (DE) | 2009-12-22 | — | — | US | claimed |
| US-20040019083-A1 | Asymmetric synthesis of (S,S,R)-(-)-actinonin and its analogs and uses therefor | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2004-01-29 | — | — | US | claimed |
| EP-1372692-A2 | ASYMMETRIC SYNTHESIS OF (S, S, R)-(-)-ACTINONIN AND ITS ANALOGS AND USES THEREFOR | Sloan Kettering Institute For Cancer Research (US) | 2004-01-02 | — | — | EP | claimed |
| EP-1334085-A1 | SULFAMIDES AS GAMMA-SECRETASE INHIBITORS | MERCK SHARP & DOHME LTD. (GB) | 2003-08-13 | — | — | EP | claimed |
| US-20020198156-A1 | Asymmetric synthesis of (S,S,R)-(-)-actinonin and its analogs and uses therefor | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2002-12-26 | — | — | US | claimed |
| WO-2002094792-A1 | HERBICIDAL SUBSTITUTED BENZOYLPYRAZOLES | BAYER CROPSCIENCE AG (DE) | 2002-11-28 | — | — | WO | claimed |
| WO-2002092574-A1 | SUBSTITUTED BENZOYLCYCLOHEXENONES AND THEIR USE AS HERBICIDAL AGENTS | BAYER CROPSCIENCE AG (DE) | 2002-11-21 | — | — | WO | claimed |
| WO-2002074050-A2 | ASYMMETRIC SYNTHESIS OF (S, S, R)-(-)-ACTINONIN AND ITS ANALOGS AND USES THEREFOR | SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2002-09-26 | — | — | WO | claimed |
| WO-2002036555-A1 | SULFAMIDES AS GAMMA-SECRETASE INHIBITORS | MERCK SHARP & DOHME LIMITED (GB) | 2002-05-10 | — | — | WO | claimed |
| WO-1992002259-A1 | NOVEL COMPOSITIONS FOR MAGNETIC RESONANCE IMAGING | MALLINCKRODT MEDICAL, INC. (US) | 1992-02-20 | — | — | WO | claimed |
| US-5077037-A | Novel compositions for magnetic resonance imaging | MALLINCKRODT MEDICAL, INC. (US) | 1991-12-31 | — | — | US | claimed |