Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.56 |
| ▸ | KRAS | P01116 | 4/20 | 0.56 |
| ▸ | RAF1 | P04049 | 4/20 | 0.56 |
| ▸ | KDR | P35968 | 4/20 | 0.56 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.56 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 5/20 | 0.40 |
| ▸ | SRC | P12931 | 5/20 | 0.39 |
| ▸ | LYN | P07948 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5057563 | 0.88 | BRAF (0.55) | BRAFKRASRAF1KDRMAP2K2 | |
| SCHEMBL5065371 | 0.84 | BRAF (0.81) | BRAFKRASRAF1KDRMAP2K2 | |
| SCHEMBL5062468 | 0.79 | BRAF (0.59) | BRAFKRASRAF1KDRMAP2K2 | |
| SCHEMBL4279929 | 0.77 | BRAF (0.53) | BRAFKRASRAF1KDRMAP2K2 | |
| SCHEMBL5061367 | 0.76 | BRAF (0.52) | BRAFKRASRAF1KDRMAP2K2 | |
| SCHEMBL4423666 | 0.74 | BRAF (0.85) | BRAFKRASRAF1KDRMAP2K2 | |
| SCHEMBL22538095 | 0.73 | BRAF (0.73) | BRAFKRASRAF1KDRMAP2K2 | |
| SCHEMBL4422853 | 0.72 | BRAF (0.66) | BRAFKRASRAF1KDRMAP2K2 | |
| SCHEMBL4427855 | 0.72 | BRAF (0.65) | BRAFKRASRAF1KDRMAP2K2 | |
| SCHEMBL27218164 | 0.72 | BRAF (1.00) | BRAFKRASRAF1KDRMAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063897-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008034008-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC. (US) | 2008-03-20 | — | — | WO | disclosed |