Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.45 |
| ▸ | RAF1 | P04049 | 8/20 | 0.45 |
| ▸ | KDR | P35968 | 7/20 | 0.45 |
| ▸ | KRAS | P01116 | 6/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 5/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ARAF | P10398 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.35 |
| ▸ | CSK | P41240 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5065436 | 0.87 | BRAF (0.57) | BRAFRAF1KDRKRASMAP2K2 | |
| SCHEMBL5065293 | 0.87 | BRAF (0.47) | BRAFRAF1KDRKRASMAP2K2 | |
| SCHEMBL4552592 | 0.86 | BRAF (0.49) | BRAFRAF1KDRKRASMAP2K2 | |
| SCHEMBL4552593 | 0.86 | BRAF (0.49) | BRAFRAF1KDRKRASMAP2K2 | |
| SCHEMBL4277930 | 0.81 | BRAF (0.63) | BRAFRAF1KDRKRASMAP2K2 | |
| SCHEMBL5062732 | 0.79 | BRAF (0.54) | BRAFRAF1KDRKRASMAP2K2 | |
| SCHEMBL5062602 | 0.79 | BRAF (0.55) | BRAFRAF1KDRKRASMAP2K2 | |
| SCHEMBL5061840 | 0.78 | BRAF (0.69) | BRAFRAF1KDRKRASMAP2K2 | |
| SCHEMBL4423737 | 0.77 | BRAF (0.56) | BRAFRAF1KDRKRASMAP2K2 | |
| SCHEMBL5061446 | 0.77 | BRAF (0.56) | BRAFRAF1KDRKRASMAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063897-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008034008-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC. (US) | 2008-03-20 | — | — | WO | disclosed |