Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL63714 | 0.95 | FGFR1 (0.45) | FGFR1FGFR3FGFR2HDAC3HDAC2 | |
| SCHEMBL4553987 | 0.90 | FGFR2 (0.36) | FGFR1FGFR3FGFR2HDAC3HDAC2 | |
| SCHEMBL4566306 | 0.89 | FGFR2 (0.38) | FGFR1FGFR3FGFR2HDAC3HDAC2 | |
| SCHEMBL4554749 | 0.88 | FGFR2 (0.37) | FGFR1FGFR3FGFR2HDAC3HDAC2 | |
| SCHEMBL4553724 | 0.88 | HDAC3 (0.34) | FGFR1FGFR3FGFR2HDAC3HDAC2 | |
| SCHEMBL63243 | 0.86 | FGFR2 (0.39) | FGFR1FGFR3FGFR2KDR | |
| SCHEMBL65366 | 0.85 | FGFR2 (0.40) | FGFR1FGFR3FGFR2 | |
| SCHEMBL64110 | 0.84 | FGFR2 (0.40) | FGFR1FGFR3FGFR2KDR | |
| SCHEMBL63669 | 0.83 | FGFR3 (0.37) | FGFR1FGFR3FGFR2HDAC3HDAC2 | |
| SCHEMBL64180 | 0.82 | FGFR2 (0.40) | FGFR1FGFR3FGFR2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |