Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1597902 | 0.90 | PIK3CD (0.62) | PIK3CDPIK3CGBTKPIK3C2B | |
| SCHEMBL1598342 | 0.87 | PIK3CD (0.58) | PIK3CDPIK3CGBTKPIK3C2B | |
| SCHEMBL1598125 | 0.83 | PIK3CD (0.66) | PIK3CDPIK3CGPIK3C2B | |
| SCHEMBL1596827 | 0.80 | PIK3CD (0.77) | PIK3CDPIK3CGPIK3C2B | |
| SCHEMBL13973987 | 0.80 | PIK3CG (0.65) | PIK3CDPIK3CGPIK3C2B | |
| SCHEMBL1598104 | 0.79 | PIK3CD (0.61) | PIK3CDPIK3CG | |
| SCHEMBL4563468 | 0.77 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3C2BMAPK13MAPK12 | |
| SCHEMBL1598996 | 0.77 | PIK3CD (0.72) | PIK3CDPIK3CGPIK3C2B | |
| SCHEMBL1598173 | 0.76 | PIK3CD (1.00) | PIK3CDPIK3CGPIK3C2B | |
| SCHEMBL1597854 | 0.76 | PIK3CD (0.59) | PIK3CDPIK3CGBTKPIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132207-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008118454-A2 | DERIVATIVES OF QUINOLINE OR BENZOPYRAZINE AND THEIR USES FOR THE TREATMENT OF (INTER ALIA) INFLAMMATORY DISEASES, AUTOIMMUNE DISEASES OR VARIOUS KINDS OF CANCER | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |