Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.73 |
| ▸ | RAF1 | P04049 | 7/20 | 0.73 |
| ▸ | KDR | P35968 | 6/20 | 0.51 |
| ▸ | KRAS | P01116 | 5/20 | 0.51 |
| ▸ | SRC | P12931 | 4/20 | 0.51 |
| ▸ | ABL1 | P00519 | 3/20 | 0.51 |
| ▸ | ARAF | P10398 | 2/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.51 |
| ▸ | CSK | P41240 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.51 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.51 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4552969 | 0.83 | BRAF (0.62) | BRAFRAF1KDRKRASSRC | |
| SCHEMBL4553048 | 0.81 | BRAF (0.71) | BRAFRAF1KDRKRASSRC | |
| SCHEMBL5065201 | 0.80 | BRAF (0.69) | BRAFRAF1KDRKRASSRC | |
| SCHEMBL4432549 | 0.79 | BRAF (0.73) | BRAFRAF1KDRKRASSRC | |
| SCHEMBL5063022 | 0.79 | RAF1 (0.68) | BRAFRAF1SRCABL1MAPK14 | |
| SCHEMBL5065339 | 0.79 | RAF1 (0.68) | BRAFRAF1SRCABL1MAPK14 | |
| SCHEMBL5065267 | 0.79 | BRAF (0.68) | BRAFRAF1KDRKRASSRC | |
| SCHEMBL4422767 | 0.79 | BRAF (0.68) | BRAFRAF1KDRKRASSRC | |
| SCHEMBL4278984 | 0.79 | BRAF (0.68) | BRAFRAF1KDRKRASSRC | |
| SCHEMBL5062552 | 0.78 | BRAF (0.66) | BRAFRAF1KDRKRASSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063897-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | claimed |
| WO-2008034008-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC. (US) | 2008-03-20 | — | — | WO | claimed |