Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 16/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14369011 | 1.00 | CYP2D6 (0.41) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4565886 | 0.95 | CYP2D6 (0.40) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4565887 | 0.95 | CYP2D6 (0.40) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14368915 | 0.95 | CYP2D6 (0.40) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5661820 | 0.95 | CYP2D6 (0.40) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4553058 | 0.95 | CYP2D6 (0.40) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14368871 | 0.95 | CYP2D6 (0.40) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14368862 | 0.95 | CYP2D6 (0.40) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4553057 | 0.95 | CYP2D6 (0.40) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5663297 | 0.95 | CYP2D6 (0.40) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024359-A1 | COMPOUNDS THAT ARE AGONISTS OF MUSCARINIC RECEPTORS AND THAT MAY BE EFFECTIVE IN TREATING PAIN, ALZHEIMER'S DECEASE AND/OR SCHIZOPHRENIA | AstraZeneca AB (SE) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007126362-A1 | COMPOUNDS THAT ARE AGONISTS OF MUSCARINIC RECEPTORS AND THAT MAY BE EFFECTIVE IN TREATING PAIN, ALZHEIMER'S DISEASE AND/OR SCHIZOPHRENIA | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | WO | disclosed |