Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.58 |
| ▸ | FLT3 | P36888 | 8/20 | 0.57 |
| ▸ | FLT4 | P35916 | 5/20 | 0.57 |
| ▸ | KDR | P35968 | 5/20 | 0.57 |
| ▸ | KIT | P10721 | 2/20 | 0.57 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 6/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553350 | 1.00 | NTRK1 (0.58) | NTRK1FLT3FLT4KDRKIT | |
| SCHEMBL4553355 | 0.95 | FLT3 (0.57) | NTRK1FLT3FLT4KDRKIT | |
| SCHEMBL4124627 | 0.90 | NTRK1 (0.71) | NTRK1FLT3FLT4KDRKIT | |
| SCHEMBL4002779 | 0.90 | NTRK1 (0.71) | NTRK1FLT3FLT4KDRKIT | |
| SCHEMBL397409 | 0.86 | NTRK1 (0.69) | NTRK1FLT3FLT4KDRKIT | |
| SCHEMBL397408 | 0.86 | NTRK1 (0.69) | NTRK1FLT3FLT4KDRKIT | |
| SCHEMBL5001641 | 0.86 | FLT3 (0.59) | NTRK1FLT3FLT4KDRKIT | |
| SCHEMBL396704 | 0.86 | NTRK1 (0.76) | NTRK1FLT3FLT4KDRKIT | |
| SCHEMBL396703 | 0.86 | NTRK1 (0.76) | NTRK1FLT3FLT4KDRKIT | |
| SCHEMBL396340 | 0.82 | NTRK2 (0.69) | NTRK1FLT3FLT4KDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814545-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-06-10 | — | — | EP | disclosed |
| EP-1814545-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006052936-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-18 | — | — | WO | disclosed |