Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 7/20 | 0.34 |
| ▸ | HTR6 | P50406 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1803283 | 0.87 | POLB (0.36) | POLBBRD4HTR6ALDH1A1KDM4E | |
| SCHEMBL1800406 | 0.85 | BRD4 (0.46) | POLBBRD4HTR6ALDH1A1KDM4E | |
| SCHEMBL1794734 | 0.83 | BRD4 (0.35) | POLBBRD4HTR6ALDH1A1HTT | |
| SCHEMBL1795815 | 0.82 | POLB (0.36) | POLBBRD4HTR6ALDH1A1CCNC | |
| SCHEMBL1797528 | 0.81 | BRD4 (0.34) | POLBBRD4HTR6ALDH1A1HTT | |
| SCHEMBL2752909 | 0.81 | PDPK1 (0.39) | POLBBRD4HTR6ALDH1A1HTT | |
| SCHEMBL1798526 | 0.81 | BRD4 (0.51) | POLBBRD4HTR6ALDH1A1KDM4E | |
| SCHEMBL1799105 | 0.81 | POLB (0.34) | POLBBRD4HTR6ALDH1A1CCNC | |
| SCHEMBL1796311 | 0.81 | HTR2C (0.37) | POLBBRD4ALDH1A1KDM4EHTT | |
| SCHEMBL8184787 | 0.80 | POLB (0.36) | POLBBRD4HTR6ALDH1A1CCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125801-A1 | THE USE OF 7-AZAINDOLES IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | Eisai R&D Management Co., Ltd. (JP) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008095943-A1 | THE USE OF 7-AZAINDOLES IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | EISAI R&D MANAGEMENT CO. LTD. (JP) | 2008-08-14 | — | — | WO | disclosed |