Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 11/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 11/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCND3 | P30281 | 1/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 8/20 | 0.44 |
| ▸ | PLK1 | P53350 | 8/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | MELK | Q14680 | 1/20 | 0.41 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.41 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.41 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3504377 | 0.94 | CDK2 (0.53) | CDK2CCNA2CCNA1CDK4CCND3 | |
| SCHEMBL3504465 | 0.93 | CDK2 (0.54) | CDK2CCNA2CCNA1CDK4CCND3 | |
| SCHEMBL3503406 | 0.90 | CDK2 (0.54) | CDK2CCNA2CCNA1CDK4CCND3 | |
| SCHEMBL4552571 | 0.86 | CDK2 (0.51) | CDK2CCNA2CCNA1CDK4CCND3 | |
| SCHEMBL4158636 | 0.83 | CDK2 (0.51) | CDK2CCNA2CCNA1CDK4CCND3 | |
| SCHEMBL3504358 | 0.83 | CDK2 (0.53) | CDK2CCNA2CCNA1CDK4CCND3 | |
| SCHEMBL1559150 | 0.82 | CCNA2 (0.66) | CDK2CCNA2CCNA1CDK4CCND3 | |
| SCHEMBL3503566 | 0.82 | CDK2 (0.54) | CDK2CCNA2CCNA1CDK4CCND3 | |
| SCHEMBL9940927 | 0.81 | CDK2 (0.53) | CDK2CCNA2CCNA1CDK4CCND3 | |
| SCHEMBL9940556 | 0.80 | PIM1 (0.55) | CDK2CCNA2CCNA1CDK4CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125822-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008074788-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2008-06-26 | — | — | WO | disclosed |