Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3515386 | 1.00 | KMT2A (0.32) | KMT2AHDAC8MEN1L3MBTL1NFKB1 | |
| SCHEMBL4553965 | 0.91 | HSD17B10 (0.33) | KMT2AHDAC8MEN1L3MBTL1 | |
| SCHEMBL3516307 | 0.86 | SMN1; SMN2 (0.35) | HDAC8 | |
| SCHEMBL3511567 | 0.86 | KMT2A (0.31) | KMT2AHDAC8MEN1L3MBTL1 | |
| SCHEMBL3512985 | 0.82 | KMT2A (0.34) | KMT2AHDAC8MEN1L3MBTL1NFKB1 | |
| SCHEMBL30722411 | 0.78 | ADORA1 (0.37) | KMT2AMEN1L3MBTL1 | |
| SCHEMBL8142975 | 0.76 | HDAC8 (0.32) | HDAC8 | |
| SCHEMBL20669349 | 0.76 | ADORA1 (0.35) | KMT2AMEN1L3MBTL1 | |
| SCHEMBL10138509 | 0.73 | HDAC8 (0.35) | HDAC8 | |
| SCHEMBL20868676 | 0.73 | SMN1; SMN2 (0.40) | KMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134717-A2 | INHIBITORS OF SERINE PROTEASES | Vertex Pharmceuticals Incorporated (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008106058-A2 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-09-04 | — | — | WO | disclosed |