Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PHGDH | O43175 | 8/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL965506 | 0.91 | MAPT (0.39) | SMN1; SMN2MAPTNR2F2HTTL3MBTL1 | |
| SCHEMBL965508 | 0.91 | MAPT (0.39) | SMN1; SMN2MAPTNR2F2HTTL3MBTL1 | |
| SCHEMBL962725 | 0.90 | MAPT (0.35) | SMN1; SMN2MAPTNR2F2HTTL3MBTL1 | |
| SCHEMBL962726 | 0.90 | MAPT (0.35) | SMN1; SMN2MAPTNR2F2HTTL3MBTL1 | |
| SCHEMBL4554061 | 0.90 | MAPT (0.38) | SMN1; SMN2MAPTNR2F2HTTL3MBTL1 | |
| SCHEMBL5116549 | 0.90 | MAPT (0.38) | SMN1; SMN2MAPTNR2F2HTTL3MBTL1 | |
| SCHEMBL965585 | 0.88 | MAPT (0.36) | SMN1; SMN2MAPTNR2F2HTTL3MBTL1 | |
| SCHEMBL965582 | 0.88 | MAPT (0.36) | SMN1; SMN2MAPTNR2F2HTTL3MBTL1 | |
| SCHEMBL965347 | 0.88 | NPY5R (0.41) | SMN1; SMN2MAPTNR2F2HTTMEN1 | |
| SCHEMBL964832 | 0.88 | MAPT (0.36) | SMN1; SMN2MAPTNR2F2HTTPHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |