Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.38 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.38 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3199435 | 0.89 | NPC1 (0.48) | NPC1RAB9ACHRNA7ACHETP53 | |
| SCHEMBL3222808 | 0.84 | NPC1 (0.48) | NPC1RAB9ACHRNA7ACHETP53 | |
| SCHEMBL3202564 | 0.82 | NPC1 (0.48) | NPC1RAB9ACHRNA7ACHETP53 | |
| SCHEMBL13490431 | 0.81 | NPC1 (0.48) | NPC1RAB9ACHRNA7ACHETP53 | |
| Hydrochloric Acid SCHEMBL3224048 | 0.80 | NPC1 (0.47) | NPC1RAB9ACHRNA7ACHETP53 | |
| SCHEMBL3199540 | 0.80 | NPC1 (0.50) | NPC1RAB9ACHRNA7ACHETP53 | |
| SCHEMBL13490310 | 0.80 | NPC1 (0.50) | NPC1RAB9ACHRNA7ACHETP53 | |
| SCHEMBL3210950 | 0.80 | NPC1 (0.46) | NPC1RAB9ACHRNA7ACHETP53 | |
| SCHEMBL13490428 | 0.79 | NPC1 (0.49) | NPC1RAB9ACHRNA7ACHETP53 | |
| SCHEMBL3223316 | 0.79 | NPC1 (0.49) | NPC1RAB9ACHRNA7ACHETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121626-A1 | BENZIMIDAZOLE DERIVATIVES | Pfizer Products Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008075196-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2008-06-26 | — | — | WO | disclosed |