Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3686407 | 0.82 | TDP1 (0.47) | TDP1ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL30861009 | 0.81 | TDP1 (0.46) | TDP1ALDH1A1LMNAHTTNOS1 | |
| SCHEMBL27228011 | 0.81 | TDP1 (0.46) | TDP1ALDH1A1LMNAHTTNOS1 | |
| SCHEMBL6118688 | 0.79 | TDP1 (0.44) | TDP1ALDH1A1LMNAHTTNOS1 | |
| SCHEMBL27227989 | 0.79 | TDP1 (0.44) | TDP1ALDH1A1LMNAHTTNOS1 | |
| SCHEMBL25290375 | 0.78 | RECQL (0.53) | TDP1ALDH1A1NOS1MAPTTSHR | |
| SCHEMBL6117729 | 0.78 | TDP1 (0.43) | TDP1ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL2049090 | 0.78 | RECQL (0.53) | TDP1ALDH1A1NOS1MAPTTSHR | |
| SCHEMBL30491733 | 0.78 | RECQL (0.53) | TDP1ALDH1A1NOS1MAPTTSHR | |
| SCHEMBL15081284 | 0.78 | TDP1 (0.43) | TDP1ALDH1A1LMNAHTTNOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057168-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008028141-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2008-03-06 | — | — | WO | disclosed |