Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.46 |
| ▸ | CTSD | P07339 | 3/20 | 0.46 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.46 |
| ▸ | REN | P00797 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4436490 | 0.80 | BACE1 (0.47) | BACE1CTSDBACE2RENAPP | |
| SCHEMBL4435672 | 0.78 | BACE1 (0.45) | BACE1CTSDBACE2RENAPP | |
| SCHEMBL4436358 | 0.76 | BACE1 (0.44) | BACE1CTSDBACE2RENAPP | |
| SCHEMBL4442013 | 0.76 | BACE1 (0.44) | BACE1CTSDBACE2RENAPP | |
| SCHEMBL21993239 | 0.75 | BACE1 (0.57) | BACE1CTSDBACE2RENAPP | |
| SCHEMBL27740597 | 0.74 | BACE1 (0.47) | BACE1CTSDBACE2RENCYP3A4 | |
| SCHEMBL27774263 | 0.74 | BACE1 (0.47) | BACE1CTSDBACE2RENCYP3A4 | |
| SCHEMBL4311809 | 0.74 | BACE1 (0.77) | BACE1CTSDBACE2RENAPP | |
| SCHEMBL27774265 | 0.73 | BACE1 (0.62) | BACE1CTSDBACE2REN | |
| SCHEMBL27774262 | 0.73 | BACE1 (0.52) | BACE1CTSDBACE2REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137161-A1 | AMINO-5-[SUBSTITUTED-4-(DIFLUOROMETHOXY)PHENYL]-5- PHENYLIMIDAZOLONE COMPOUNDS AS ß-SECRETASE INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008115552-A1 | AMINO-5-[SUBSTITUTED-4-(DIFLUOROMETHOXY)PHENYL]-5- PHENYLIMIDAZOLONE COMPOUNDS AS ß-SECRETASE INHIBITORS | WYETH (US) | 2008-09-25 | — | — | WO | disclosed |