Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | BTK | Q06187 | 4/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 3/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 8/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 7/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4565715 | 0.88 | MAP4K4 (0.43) | MAP4K4BTKJAK3AURKAPDPK1 | |
| SCHEMBL4554934 | 0.86 | BTK (0.42) | MAP4K4BTKJAK3AURKAPDPK1 | |
| SCHEMBL4555708 | 0.85 | PIM2 (0.55) | MAP4K4BTKPIM2PIM3PIM1 | |
| SCHEMBL11907439 | 0.85 | PIM2 (0.55) | MAP4K4BTKPIM2PIM3PIM1 | |
| SCHEMBL4555796 | 0.82 | F10 (0.41) | MAP4K4BTKJAK3AURKAPDPK1 | |
| SCHEMBL1710581 | 0.81 | MAP4K4 (0.57) | MAP4K4BTKJAK3AURKAPDPK1 | |
| SCHEMBL1710229 | 0.81 | MAP4K4 (0.57) | MAP4K4BTKJAK3AURKAPDPK1 | |
| SCHEMBL1710231 | 0.81 | MAP4K4 (0.57) | MAP4K4BTKJAK3AURKAPDPK1 | |
| SCHEMBL4564058 | 0.80 | MAP4K4 (0.55) | MAP4K4BTKJAK3AURKAPDPK1 | |
| SCHEMBL13833280 | 0.80 | MAP4K4 (0.55) | MAP4K4BTKJAK3AURKAPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |