Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | NOS1 | P29475 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | S100A4 | P26447 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29687237 | 1.00 | TDP1 (0.50) | TDP1NOS1ALDH1A1POLBCYP1A2 | |
| SCHEMBL30410440 | 0.80 | TDP1 (0.50) | TDP1NOS1ALDH1A1POLBCYP1A2 | |
| SCHEMBL27779498 | 0.80 | TDP1 (0.50) | TDP1NOS1ALDH1A1POLBCYP1A2 | |
| SCHEMBL27983393 | 0.80 | TDP1 (0.50) | TDP1NOS1ALDH1A1POLBCYP1A2 | |
| SCHEMBL27758503 | 0.80 | TDP1 (0.50) | TDP1NOS1ALDH1A1POLBCYP1A2 | |
| SCHEMBL618730 | 0.80 | TDP1 (0.50) | TDP1NOS1ALDH1A1POLBCYP1A2 | |
| SCHEMBL27227871 | 0.78 | TDP1 (0.44) | TDP1NOS1ALDH1A1POLBCYP1A2 | |
| SCHEMBL30860978 | 0.78 | TDP1 (0.44) | TDP1NOS1ALDH1A1POLBCYP1A2 | |
| SCHEMBL3686407 | 0.78 | TDP1 (0.47) | TDP1NOS1ALDH1A1POLBCYP1A2 | |
| SCHEMBL15081284 | 0.77 | TDP1 (0.43) | TDP1NOS1ALDH1A1POLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107635558-A | Bu Luomo domain inhibitor | 赛尔基因昆蒂赛尔研究公司 | 2018-01-26 | — | — | CN | disclosed |
| CN-104902893-B | Mineralocorticoid receptor antagonists | 默沙东公司 | 2017-11-28 | — | — | CN | disclosed |
| CN-106604997-A | Inhibitors of lysine specific demethylase-1 | 赛尔基因昆蒂赛尔研究公司 | 2017-04-26 | — | — | CN | disclosed |
| CN-101553492-A | RAF inhibitor compounds and methods of use thereof | ARRAY BIOPHARMA INC (US) | 2009-10-07 | — | — | CN | disclosed |
| EP-2057168-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008028141-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2008-03-06 | — | — | WO | disclosed |