Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 13/20 | 0.65 |
| ▸ | CDK2 | P24941 | 8/20 | 0.59 |
| ▸ | CDK1 | P06493 | 5/20 | 0.59 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.59 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.59 |
| ▸ | IGF1R | P08069 | 2/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.49 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.48 |
| ▸ | CDK7 | P50613 | 5/20 | 0.48 |
| ▸ | CCNH | P51946 | 3/20 | 0.48 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3048139 | 0.93 | FLT3 (0.63) | FLT3CDK2CDK1CCNB1CCNE1 | |
| SCHEMBL3043711 | 0.91 | FLT3 (0.62) | FLT3CDK2CDK1CCNB1CCNE1 | |
| SCHEMBL3162405 | 0.90 | FLT3 (0.60) | FLT3CDK2CDK1CCNB1CCNE1 | |
| SCHEMBL3041597 | 0.90 | FLT3 (0.60) | FLT3CDK2CDK1CCNB1CCNE1 | |
| SCHEMBL3040112 | 0.89 | FLT3 (0.62) | FLT3CDK2CDK1CCNB1CCNE1 | |
| SCHEMBL3041623 | 0.88 | FLT3 (0.58) | FLT3CDK2CDK1CCNB1CCNE1 | |
| SCHEMBL3045421 | 0.87 | FLT3 (0.59) | FLT3CDK2CDK1CCNB1CCNE1 | |
| SCHEMBL3041619 | 0.87 | FLT3 (0.57) | FLT3CDK2CDK1CCNB1CCNE1 | |
| SCHEMBL3036401 | 0.87 | FLT3 (0.60) | FLT3CDK2CDK1CCNB1CCNE1 | |
| SCHEMBL3043746 | 0.87 | FLT3 (0.62) | FLT3CDK2CDK1CCNB1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2040546-A2 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2009-04-01 | — | — | EP | claimed |
| WO-2007149427-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2007-12-27 | — | — | WO | claimed |