Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.54 |
| ▸ | PIK3R1 | P27986 | 10/20 | 0.54 |
| ▸ | MTOR | P42345 | 7/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7898875 | 0.87 | PIK3CA (0.56) | PIK3CAPIK3R1MTORSMN1; SMN2PIK3CD | |
| SCHEMBL25391998 | 0.86 | PIK3CA (0.57) | PIK3CAPIK3R1MTORSMN1; SMN2PIK3CD | |
| SCHEMBL190498 | 0.85 | PIK3CA (0.56) | PIK3CAPIK3R1MTORSMN1; SMN2PIK3CD | |
| SCHEMBL184741 | 0.85 | PIK3CA (0.74) | PIK3CAPIK3R1MTORSMN1; SMN2PIK3CD | |
| SCHEMBL466342 | 0.85 | PIK3CA (0.56) | PIK3CAPIK3R1MTORSMN1; SMN2PIK3CD | |
| SCHEMBL13871747 | 0.85 | PIK3CA (0.56) | PIK3CAPIK3R1MTORSMN1; SMN2PIK3CD | |
| SCHEMBL1862672 | 0.84 | PIK3CA (0.53) | PIK3CAPIK3R1MTORSMN1; SMN2PIK3CD | |
| SCHEMBL189807 | 0.84 | PIK3CA (0.53) | PIK3CAPIK3R1MTORSMN1; SMN2PIK3CD | |
| SCHEMBL1088049 | 0.84 | PIK3CA (0.58) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL4076548 | 0.82 | PIK3CA (0.60) | PIK3CAPIK3R1MTORSMN1; SMN2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114950-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008073785-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2008-06-19 | — | — | WO | disclosed |