Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 18/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4019530 | 0.88 | CCR1 (0.47) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4014775 | 0.86 | CCR1 (0.55) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4019936 | 0.85 | CCR1 (0.47) | CCR1CYP2C19KCNH2 | |
| SCHEMBL27662985 | 0.85 | CCR1 (0.43) | CCR1CYP2C19KCNH2HTR7 | |
| SCHEMBL4017792 | 0.85 | CCR1 (0.45) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4020840 | 0.84 | CCR1 (0.46) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4314235 | 0.82 | SMO (0.37) | CCR1ALDH1A1 | |
| SCHEMBL4013693 | 0.81 | CCR1 (0.45) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4014926 | 0.81 | CCR1 (0.45) | CCR1CYP2C19KCNH2 | |
| SCHEMBL6171132 | 0.80 | CCR1 (0.51) | CCR1CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1691810-A4 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1691810-A1 | SUBSTITUTED PIPERAZINES | ChemoCentryx Inc (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056015-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2005-06-23 | — | — | WO | disclosed |