Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 13/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 9/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2933682 | 0.92 | PTPN1 (0.49) | PTPN1PTPN2 | |
| SCHEMBL3085123 | 0.91 | PTPN1 (0.51) | PTPN1PTPN2APP | |
| SCHEMBL2937302 | 0.82 | PTPN1 (0.47) | PTPN1PTPN2 | |
| SCHEMBL3228343 | 0.80 | PTPN1 (0.47) | PTPN1PTPN2 | |
| SCHEMBL2934233 | 0.80 | PTPN1 (0.48) | PTPN1PTPN2 | |
| SCHEMBL3923934 | 0.79 | PTPN1 (0.53) | PTPN1PTPN2 | |
| SCHEMBL3205271 | 0.77 | IAPP (0.51) | PTPN1PTPN2 | |
| SCHEMBL2937456 | 0.77 | PTPN1 (0.48) | PTPN1PTPN2 | |
| SCHEMBL3225559 | 0.77 | PTPN1 (0.48) | PTPN1PTPN2 | |
| SCHEMBL2928483 | 0.77 | PTPN1 (0.51) | PTPN1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089026-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE PROMOTION OF PHYSIOLOGICAL CARDIAC HYPERTROPHY | Novartis AG (CH) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008070552-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE PROMOTION OF PHYSIOLOGICAL CARDIAC HYPERTROPHY | NOVARTIS AG (CH) | 2008-06-12 | — | — | WO | disclosed |