Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 13/20 | 0.41 |
| ▸ | RET | P07949 | 5/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 8/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | TPO | P07202 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4557234 | 0.84 | PIM1 (0.43) | PIM1RETPIM2KDRMPO | |
| SCHEMBL4595733 | 0.76 | PIM1 (0.71) | PIM1RETPIM2KDR | |
| SCHEMBL4340335 | 0.62 | FYN (0.44) | PIM1RETPIM2 | |
| SCHEMBL4342695 | 0.61 | SCN5A (0.48) | PIM1PIM2KCNH2 | |
| SCHEMBL4332316 | 0.61 | RET (0.63) | PIM1RETKDR | |
| SCHEMBL4595639 | 0.60 | PIM1 (0.60) | PIM1RETPIM2 | |
| SCHEMBL4594795 | 0.60 | PIM1 (0.44) | PIM1RETPIM2 | |
| SCHEMBL19095652 | 0.58 | LRRK2 (0.57) | PIM1PIM2KCNH2BRAF | |
| SCHEMBL20370288 | 0.58 | LCK (0.49) | KDRMPOKCNH2BRAF | |
| SCHEMBL21193665 | 0.57 | RIPK2 (0.48) | PIM1PIM2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049539-A1 | PYRAZOLOPYRIMIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME. | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-04-22 | — | — | EP | claimed |
| WO-2007147647-A1 | PYRAZOLOPYRIMIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME. | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-12-27 | — | — | WO | claimed |