Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 5/20 | 0.54 |
| ▸ | MAP3K5 | Q99683 | 4/20 | 0.40 |
| ▸ | MAP3K6 | O95382 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | SUV39H1 | O43463 | 1/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583323 | 0.91 | PAK1 (0.61) | PAK1MAP3K5MAP3K6MEN1KMT2A | |
| SCHEMBL4017305 | 0.85 | PAK1 (0.55) | PAK1MAP3K5MAP3K6MEN1KMT2A | |
| SCHEMBL4557238 | 0.82 | MALT1 (0.37) | PAK1MALT1SUV39H1PRMT1SMYD3 | |
| SCHEMBL4024025 | 0.82 | PAK1 (0.63) | PAK1MAP3K5MAP3K6MEN1KMT2A | |
| SCHEMBL4024042 | 0.80 | PAK1 (0.71) | PAK1MEN1KMT2AP2RX7MALT1 | |
| SCHEMBL4016348 | 0.80 | MEN1 (0.49) | PAK1MAP3K5MEN1KMT2AP2RX7 | |
| SCHEMBL4016410 | 0.79 | PAK1 (0.64) | PAK1MEN1KMT2AP2RX7MALT1 | |
| SCHEMBL4024568 | 0.79 | PAK1 (0.68) | PAK1MAP3K5MAP3K6MEN1KMT2A | |
| SCHEMBL4019298 | 0.79 | PAK1 (0.54) | PAK1MEN1KMT2AP2RX7MALT1 | |
| SCHEMBL4018498 | 0.78 | PAK1 (0.62) | PAK1MEN1KMT2AP2RX7MALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066654-A1 | N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS | Bayer Schering Pharma AG (DE) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008028691-A1 | N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-13 | — | — | WO | disclosed |