Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 4/20 | 0.38 |
| ▸ | GSR | P00390 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL597053 | 0.92 | ELANE (0.52) | ELANEKMT2AMEN1ADRB1HTR1A | |
| SCHEMBL597779 | 0.92 | ELANE (0.59) | ELANEKMT2AMEN1ADRB1HTR1A | |
| SCHEMBL2695330 | 0.89 | ELANE (0.65) | ELANEKMT2AMEN1CYP2C9POLB | |
| SCHEMBL596968 | 0.88 | ELANE (0.51) | ELANEKMT2AMEN1ADRB1HTR1A | |
| SCHEMBL4452188 | 0.84 | KMT2A (0.51) | ELANEKMT2AMEN1POLBNOTUM | |
| SCHEMBL12327865 | 0.84 | KMT2A (0.51) | ELANEKMT2AMEN1POLBNOTUM | |
| Azd-6553 SCHEMBL3705053 | 0.82 | ELANE (0.64) | ELANEKMT2AMEN1CYP2C9CTSK | |
| SCHEMBL1603348 | 0.80 | ELANE (0.65) | ELANEKMT2AMEN1CYP2C9CYP1A2 | |
| SCHEMBL525061 | 0.80 | ELANE (0.74) | ELANEKMT2AMEN1CYP2C9CTSK | |
| SCHEMBL595622 | 0.80 | ELANE (0.62) | ELANEKMT2AMEN1CYP2C9CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018377-A1 | 2-PYRAZINONE DERIVATIVES FOR THE TREATMENT OF DISEASE OR CONDITION IN WHICH INHIBITION OF NEUTROPHIL ELASTASE ACTIVITY IS BENEFICIAL. | Astra Zeneca AB (SE) | 2009-01-28 | — | — | EP | disclosed |
| WO-2007129963-A1 | 2-PYRAZINONE DERIVATIVES FOR THE TREATMENT OF DISEASE OR CONDITION IN WHICH INHIBITION OF NEUTROPHIL ELASTASE ACTIVITY IS BENEFICIAL. | ASTRAZENECA AB (SE) | 2007-11-15 | — | — | WO | disclosed |