Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.47 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 3/20 | 0.34 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL226755 | 1.00 | ESR1 (0.47) | ESR1ESR2CYP26A1DRD2DRD3 | |
| SCHEMBL229279 | 0.93 | ESR1 (0.48) | ESR1ESR2CYP26A1DRD2DRD3 | |
| SCHEMBL228223 | 0.93 | ESR1 (0.48) | ESR1ESR2CYP26A1DRD2DRD3 | |
| SCHEMBL228544 | 0.93 | ESR1 (0.52) | ESR1ESR2CYP26A1DRD2DRD3 | |
| SCHEMBL228883 | 0.92 | ESR1 (0.48) | ESR1ESR2CYP26A1DRD2DRD3 | |
| SCHEMBL229964 | 0.92 | ESR1 (0.48) | ESR1ESR2CYP26A1DRD2DRD3 | |
| SCHEMBL228519 | 0.90 | ESR1 (0.51) | ESR1ESR2CYP26A1DRD2DRD3 | |
| SCHEMBL229683 | 0.90 | ESR1 (0.51) | ESR1ESR2CYP26A1DRD2DRD3 | |
| SCHEMBL229729 | 0.90 | ESR1 (0.40) | ESR1ESR2CYP26A1DRD2DRD3 | |
| SCHEMBL228403 | 0.90 | ESR1 (0.47) | ESR1ESR2CYP26A1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612114-B2 | Such as (R)-6-{2-{ethyl[4-(2-ethylaminoethyl)benzyl]amino }-4-methoxyphenyl }-5,6,7,8-tetrahydronaphthalen-2-ol; osteoporosis; breast cancer | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |