Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 1/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 6/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.42 |
| ▸ | FLT4 | P35916 | 5/20 | 0.42 |
| ▸ | FLT3 | P36888 | 5/20 | 0.42 |
| ▸ | PLK4 | O00444 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | SRC | P12931 | 3/20 | 0.42 |
| ▸ | TEK | Q02763 | 3/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.42 |
| ▸ | CDK4 | P11802 | 3/20 | 0.42 |
| ▸ | CCND1 | P24385 | 3/20 | 0.42 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | INSR | P06213 | 2/20 | 0.42 |
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4557937 | 0.84 | MAOB (0.41) | CDK4CCND1ABL1CDK2GSK3B | |
| SCHEMBL4557944 | 0.84 | KDR (0.45) | CYP1A1CYP1B1KDRPDGFRBFLT4 | |
| SCHEMBL4557955 | 0.82 | PIK3CA (0.41) | PDGFRBCDK4CCND1ABL1CDK2 | |
| SCHEMBL4557411 | 0.81 | MAPT (0.42) | PDGFRBCDK4CCND1ABL1CDK2 | |
| SCHEMBL4556996 | 0.78 | PTPRC (0.45) | PDGFRBCDK4CCND1ABL1CDK2 | |
| SCHEMBL4557936 | 0.70 | MAOB (0.41) | PDGFRBCDK4CCND1ABL1CDK2 | |
| SCHEMBL7149485 | 0.68 | CYP2A6 (0.50) | CYP1A1CYP1B1KDRPDGFRBFLT4 | |
| SCHEMBL4420502 | 0.68 | HTR2C (0.38) | PIM1 | |
| SCHEMBL4557409 | 0.68 | MAPT (0.43) | CDK4CCND1ABL1CDK2MAOB | |
| SCHEMBL4556994 | 0.67 | PTPRC (0.47) | PDGFRBCDK4CCND1ABL1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090311217-A1 | 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090311217-A1 | 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | MTOR, RICTOR, PDPK1 | CYP1A1 1367/4885CYP1B1 808/4885KDR 1642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.