Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASAH1 | Q13510 | 3/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.47 |
| ▸ | ADA | P00813 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5407954 | 0.90 | HDAC8 (0.51) | ASAH1HDAC8DNMT3AMEN1HPGD | |
| SCHEMBL668253 | 0.89 | ASAH1 (0.51) | ASAH1HDAC8DNMT3AADAMEN1 | |
| SCHEMBL4558105 | 0.81 | ASAH1 (0.48) | ASAH1HDAC8DNMT3AADAMEN1 | |
| SCHEMBL7854777 | 0.80 | ASAH1 (0.51) | ASAH1ADAMEN1HPGDKMT2A | |
| SCHEMBL21388677 | 0.80 | ASAH1 (0.51) | ASAH1ADAMEN1HPGDKMT2A | |
| SCHEMBL21559595 | 0.80 | ASAH1 (0.51) | ASAH1ADAMEN1HPGDKMT2A | |
| SCHEMBL27846962 | 0.79 | HDAC8 (0.53) | ASAH1HDAC8DNMT3AMEN1HPGD | |
| SCHEMBL14740043 | 0.79 | MEN1 (0.48) | ASAH1HDAC8DNMT3AADAMEN1 | |
| SCHEMBL3795625 | 0.78 | HDAC8 (0.55) | ASAH1HDAC8DNMT3AMEN1HPGD | |
| SCHEMBL26202221 | 0.78 | ASAH1 (0.49) | ASAH1ADAMEN1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626964-B1 | NEW BENZIMIDAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | claimed |