Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 20/20 | 0.78 |
| ▸ | KDR | P35968 | 20/20 | 0.78 |
| ▸ | EPHB4 | P54760 | 19/20 | 0.78 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.77 |
| ▸ | FLT1 | P17948 | 4/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2296737 | 1.00 | EPHA2 (0.78) | EPHA2KDREPHB4ERBB2FLT1 | |
| Hydrochloric Acid SCHEMBL907167 | 0.99 | EPHA2 (0.77) | EPHA2KDREPHB4ERBB2FLT1 | |
| Hydrochloric Acid SCHEMBL907259 | 0.99 | EPHA2 (0.77) | EPHA2KDREPHB4ERBB2FLT1 | |
| SCHEMBL2300284 | 0.91 | EPHA2 (0.81) | EPHA2KDREPHB4ERBB2FLT1 | |
| SCHEMBL2300279 | 0.91 | EPHA2 (0.81) | EPHA2KDREPHB4ERBB2FLT1 | |
| Hydrochloric Acid SCHEMBL906821 | 0.90 | EPHA2 (0.80) | EPHA2KDREPHB4ERBB2FLT1 | |
| Hydrochloric Acid SCHEMBL906820 | 0.90 | EPHA2 (0.80) | EPHA2KDREPHB4ERBB2FLT1 | |
| SCHEMBL906814 | 0.88 | EPHA2 (1.00) | EPHA2KDREPHB4ERBB2FLT1 | |
| SCHEMBL906722 | 0.87 | EPHA2 (1.00) | EPHA2KDREPHB4ERBB2FLT1 | |
| SCHEMBL1792357 | 0.87 | EPHA2 (1.00) | EPHA2KDREPHB4ERBB2FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | disclosed |