Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.53 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 9/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1771996 | 1.00 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL1772235 | 0.92 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL1771530 | 0.92 | PIK3CD (0.69) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL1772490 | 0.91 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL456954 | 0.91 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL13578003 | 0.91 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL1772156 | 0.91 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL1771473 | 0.90 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL1118655 | 0.90 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL1771444 | 0.90 | PIK3CD (0.59) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147187-A1 | 4-CARBOXAMIDE INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF P13-KINASES | GLAXO GROUP LIMITED (GB) | 2009-12-10 | — | — | WO | disclosed |