SCHEMBL455853

SCHEMBL455853

Cn1c(=O)n([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c21

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.71
▸ KMT2A Q03164 1/20 0.71
▸ TLR7 Q9NYK1 2/20 0.69
▸ PNP P00491 3/20 0.67
▸ CYP3A4 P08684 1/20 0.54
▸ MAPT P10636 1/20 0.54
▸ HSPA5 P11021 1/20 0.44
▸ HSPA8 P11142 1/20 0.44
▸ CYP1A2 P05177 1/20 0.43
▸ LMNA P02545 3/20 0.41
▸ MTOR P42345 2/20 0.41
▸ THRB P10828 1/20 0.41
▸ MDM2 Q00987 1/20 0.41
▸ NCOA1 Q15788 1/20 0.41
▸ NCOA3 Q9Y6Q9 1/20 0.41
▸ POLB P06746 1/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.41
▸ GMNN O75496 1/20 0.41
▸ ALDH1A1 P00352 1/20 0.41
▸ TP53 P04637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26079955 1.00 MEN1 (0.71) MEN1KMT2ATLR7PNPCYP3A4
SCHEMBL23202083 1.00 MEN1 (0.71) MEN1KMT2ATLR7PNPCYP3A4
SCHEMBL10117778 1.00 MEN1 (0.71) MEN1KMT2ATLR7PNPCYP3A4
SCHEMBL6448926 0.90 PNP (0.66) MEN1KMT2ATLR7PNPCYP3A4
SCHEMBL28692399 0.88 MEN1 (0.72) MEN1KMT2ATLR7PNPCYP3A4
SCHEMBL6905072 0.87 TLR7 (0.76) MEN1KMT2ATLR7PNPCYP3A4
SCHEMBL7634608 0.87 TLR7 (0.76) MEN1KMT2ATLR7PNPCYP3A4
SCHEMBL26079973 0.87 TLR7 (0.76) MEN1KMT2ATLR7PNPCYP3A4
SCHEMBL23202214 0.87 TLR7 (0.76) MEN1KMT2ATLR7PNPCYP3A4
SCHEMBL23202549 0.87 MEN1 (0.78) MEN1KMT2ATLR7PNPCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3458 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260139030-A1 CHIMERIC PROTEINS FOR TREATING CUTANEOUS INFLAMMATION SHATTUCK LABS INC (US) 2026-05-21 — — US claimed
US-20250345406-A1 CHIMERIC PROTEINS IN AUTOIMMUNITY SHATTUCK LABS INC (US) 2025-11-13 — — US claimed
US-20250325494-A1 COMPOSITION FOR ORGAN-SPECIFIC DELIVERY OF NUCLEIC ACID THEMEDIUM THERAPEUTICS CO., LTD. (CN) 2025-10-23 — — US claimed
EP-4634380-A1 INTERNAL RIBOSOME ENTRY SITES FOR IMPROVED POLYNUCLEOTIDE TRANSLATION ModernaTX, Inc. (US) 2025-10-22 — — EP claimed
WO-2025137275-A1 NOVEL CAS NUCLEASES AND POLYNUCLEOTIDES ENCODING THE SAME MODERNATX, INC. (US) 2025-06-26 — — WO claimed
US-20250188013-A1 LIPID COMPOUND AND USE THEREOF THEMEDIUM THERAPEUTICS CO., LTD. (CN) 2025-06-12 — — US claimed
WO-2025122721-A1 CHIMERIC PROTEINS AND USES THEREOF SHATTUCK LABS, INC. (US) 2025-06-12 — — WO claimed
EP-4565692-A2 INTERNAL RIBOSOME ENTRY SITES FOR IMPROVED POLYNUCLEOTIDE TRANSLATION ModernaTX, Inc. (US) 2025-06-11 — — EP claimed
WO-2025049610-A1 MULTI-ACTION PEPTIDES SHATTUCK LABS, INC. (US) 2025-03-06 — — WO claimed
CN-119421870-A Lipid compound and application thereof 传信生物医药(苏州)有限公司 2025-02-11 — — CN claimed
US-20120251618-A1 DELIVERY AND FORMULATION OF ENGINEERED NUCLEIC ACIDS modeRNA Therapeutics (US) 2012-10-04 — — US claimed
CN-101340931-A Modulation of tlr-mediated immune responses using adaptor oligonucleotides COLEY PHARM GMBH (DE) 2009-01-07 — — CN claimed
EP-1928500-A2 MODULATION OF TLR-MEDIATED IMMUNE RESPONSES USING ADAPTOR OLIGONUCLEOTIDES Coley Pharmaceutical GmbH (DE) 2008-06-11 — — EP claimed
WO-2007038720-A2 MODULATION OF TLR-MEDIATED IMMUNE RESPONSES USING ADAPTOR OLIGONUCLEOTIDES COLEY PHARMACEUTICAL GMBH (DE) 2007-04-05 — — WO claimed
US-5317013-A Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) 1994-05-31 — — US claimed
US-4948730-A INDUCING INTERFERON PRODUCTION SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) 1990-08-14 — — US claimed
US-4746651-A ANTIBIOTIC AND ALDOGYCOSIDYL-GUANINE OR ISOXANTHOPTERIN IMMUNE RESPONSE-ENHANCING AGENT SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) 1988-05-24 — — US claimed
US-4643992-A Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) 1987-02-17 — — US claimed
EP-0112632-A2 Use of 8-substituted guanine derivatives in the manufacture of a medicament. SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) 1984-07-04 — — EP claimed
WO-1984001898-A1 MODULATION OF ANIMAL CELLULAR RESPONSES WITH COMPOSITIONS CONTAINNG 8-SUBSTITUTED GUANINE DERIVATIVES SCRIPPS CLINIC RES (US) 1984-05-24 — — WO claimed
Send feedback