Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 11/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL244755 | 0.92 | SCD (0.56) | SCDHDAC1RAB9APOLBTP53 | |
| SCHEMBL243177 | 0.90 | SCD (0.52) | SCDHDAC1RAB9APOLBTP53 | |
| SCHEMBL244279 | 0.85 | SCD (0.57) | SCDHDAC1RAB9APOLBTP53 | |
| SCHEMBL244962 | 0.84 | TSHR (0.60) | SCDHDAC1TSHRKDM4ELMNA | |
| SCHEMBL243738 | 0.84 | SCD (0.56) | SCDHDAC1RAB9APOLBTP53 | |
| SCHEMBL245118 | 0.83 | SCD (0.57) | SCDHDAC1RAB9APOLBTP53 | |
| SCHEMBL241902 | 0.83 | SCD (0.57) | SCDHDAC1RAB9APOLBTP53 | |
| SCHEMBL243779 | 0.83 | SCD (0.60) | SCDHDAC1RAB9APOLBTP53 | |
| SCHEMBL244191 | 0.82 | SCD (0.56) | SCDRAB9APOLBTP53TSHR | |
| SCHEMBL244626 | 0.82 | SCD (0.59) | SCDHDAC1RAB9APOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054408-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | Novartis Ag (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008127349-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | NOVARTIS AG (CH) | 2008-10-23 | — | — | WO | claimed |