Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 20/20 | 0.74 |
| ▸ | HSP90AB1 | P08238 | 20/20 | 0.74 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.66 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ganetespib SCHEMBL421080 | 0.89 | HSP90AA1 (0.77) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL14184042 | 0.89 | HSP90AA1 (0.77) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL1304628 | 0.87 | HSP90AA1 (0.74) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL421107 | 0.87 | HSP90AA1 (0.74) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL1306155 | 0.85 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL1864782 | 0.84 | HSP90AA1 (0.70) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL1304170 | 0.82 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL1864529 | 0.82 | HSP90AA1 (0.68) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL12634877 | 0.82 | HSP90AA1 (0.67) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL1867448 | 0.82 | HSP90AA1 (0.70) | HSP90AA1HSP90AB1HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035396-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | Synta Pharmaceuticals Corporation (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007139967-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2007-12-06 | — | — | WO | disclosed |