Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.53 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 10/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1771355 | 1.00 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| Trifluoroacetic Acid SCHEMBL17491763 | 0.96 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL1772490 | 0.95 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL13578017 | 0.93 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL1771621 | 0.93 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL1771330 | 0.93 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL1771530 | 0.92 | PIK3CD (0.69) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| Trifluoroacetic Acid SCHEMBL1771419 | 0.91 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL462411 | 0.91 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL462412 | 0.91 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147187-A1 | 4-CARBOXAMIDE INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF P13-KINASES | GLAXO GROUP LIMITED (GB) | 2009-12-10 | — | — | WO | disclosed |