Noscapine

Noscapine

SCHEMBL4559

COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 7/20 1.00
TUBB4A P04350 5/20 1.00
TUBB P07437 5/20 1.00
TUBA3C P0DPH7 5/20 1.00
TUBA1B P68363 5/20 1.00
TUBA4A P68366 5/20 1.00
TUBB4B P68371 5/20 1.00
TUBB3 Q13509 5/20 1.00
TUBB2A Q13885 5/20 1.00
TUBB8 Q3ZCM7 5/20 1.00
TUBA3E Q6PEY2 5/20 1.00
TUBA1A Q71U36 5/20 1.00
TUBA1C Q9BQE3 5/20 1.00
TUBB6 Q9BUF5 5/20 1.00
TUBB2B Q9BVA1 5/20 1.00
TUBB1 Q9H4B7 5/20 1.00
CYP2C9 P11712 4/20 1.00
CYP2C19 P33261 4/20 1.00
ABCB11 O95342 2/20 1.00
CYP1A2 P05177 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Noscapine SCHEMBL7862895 1.00 CYP3A4 (1.00) CYP3A4TUBB4ATUBBTUBA3CTUBA1B
Noscapine SCHEMBL14386820 1.00 CYP3A4 (1.00) CYP3A4TUBB4ATUBBTUBA3CTUBA1B
Noscapine SCHEMBL29365828 1.00 CYP3A4 (1.00) CYP3A4TUBB4ATUBBTUBA3CTUBA1B
Noscapine SCHEMBL10307295 1.00 CYP3A4 (1.00) CYP3A4TUBB4ATUBBTUBA3CTUBA1B
Noscapine SCHEMBL2494164 1.00 CYP3A4 (1.00) CYP3A4TUBB4ATUBBTUBA3CTUBA1B
Noscapine SCHEMBL12481369 1.00 CYP3A4 (1.00) CYP3A4TUBB4ATUBBTUBA3CTUBA1B
Noscapine SCHEMBL14400084 1.00 CYP3A4 (1.00) CYP3A4TUBB4ATUBBTUBA3CTUBA1B
Noscapine SCHEMBL1405962 0.99 CYP3A4 (1.00) CYP3A4TUBB4ATUBBTUBA3CTUBA1B
Noscapine SCHEMBL29387578 0.99 CYP3A4 (1.00) CYP3A4TUBB4ATUBBTUBA3CTUBA1B
Noscapine SCHEMBL177962 0.99 CYP3A4 (1.00) CYP3A4TUBB4ATUBBTUBA3CTUBA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 15903 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4748375-A1 PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATING ORGAN FIBROSIS-RELATED DISEASES Shionogi China Co., Ltd. (CN) 2026-05-27 EP claimed
CN-122072257-A Method for rapidly detecting poison in blood 中国科学院大连化学物理研究所 2026-05-22 CN claimed
CN-122055143-A Solid compositions containing bromhexine 第一三共健康事业株式会社 2026-05-15 CN claimed
US-20250388939-A1 RECOMBINANT HOST CELLS WITH IMPROVED PRODUCTION OF L-DOPA, DOPAMINE, S-NOROCLAURINE OR DERIVATIVES THEREOF RIVER STONE BIOTECH APS (DK) 2025-12-25 US claimed
US-20250255781-A1 PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-08-14 US claimed
US-20250248938-A1 MEDICAMENT DELIVERY FORMULATIONS, DEVICES AND METHODS HONEYWELL INTERNATIONAL INC. (US) 2025-08-07 US claimed
US-12371722-B2 Recombinant host cells with improved production of L-DOPA, dopamine, S-noroclaurine or derivatives thereof RIVER STONE BIOTECH APS (DK) 2025-07-29 US claimed
US-20250188090-A1 A METHOD FOR EXTRACTION OF ALKALOID SUN PHARMACEUTICAL INDUSTRIES (AUSTRALIA) PTY LTD (AU) 2025-06-12 US claimed
US-20250179543-A1 NORCOCLAURINE SYNTHASES WITH INCREASED ACITVITY RIVER STONE BIOTECH INC (US) 2025-06-05 US claimed
WO-2025100462-A1 SOLID COMPOSITION CONTAINING BROMHEXINE 第一三共ヘルスケア株式会社 2025-05-15 WO claimed
EP-0233932-A4 ANTICONVULSANT COMPOSITIONS AND METHOD. UNIV NEW YORK (US) 1988-04-26 EP claimed
EP-0241615-A1 A pharmaceutical composition of phenindamine having enhanced release characteristics WARNER-LAMBERT COMPANY (US) 1987-10-21 EP claimed
EP-0233932-A1 ANTICONVULSANT COMPOSITIONS AND METHOD NEW YORK UNIVERSITY (US) 1987-09-02 EP claimed
EP-0219458-A2 Medicament adsorbates and their preparation WARNER-LAMBERT COMPANY (US) 1987-04-22 EP claimed
US-4650663-A FLAKES, INTERSTITIAL SPACES WARNER-LAMBERT COMPANY (US) 1987-03-17 US claimed
WO-1987001036-A1 ANTICONVULSANT COMPOSITIONS AND METHOD NEW YORK UNIVERSITY (US) 1987-02-26 WO claimed
US-4557934-A ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE THE PROCTER & GAMBLE COMPANY (US) 1985-12-10 US claimed
EP-0132472-A1 Medicated products containing a magnesium trisilicate adsorbent with a medicament drug adsorbed thereon WARNER-LAMBERT COMPANY (US) 1985-02-13 EP claimed
US-4369172-A Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose FOREST LABORATORIES INC. (US) 1983-01-18 US claimed
US-4029797-A Process of making cough syrup with masked noscapine FISONS CORPORATION (US) 1977-06-14 US claimed