Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 18/20 | 0.74 |
| ▸ | CDK5R1 | Q15078 | 15/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | NPC1 | O15118 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.74 |
| ▸ | CDK2 | P24941 | 16/20 | 0.68 |
| ▸ | CCNA2 | P20248 | 14/20 | 0.68 |
| ▸ | CDK1 | P06493 | 5/20 | 0.68 |
| ▸ | CDK7 | P50613 | 3/20 | 0.68 |
| ▸ | CDK9 | P50750 | 3/20 | 0.68 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.68 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.68 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.68 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.68 |
| ▸ | CCNH | P51946 | 1/20 | 0.68 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.68 |
| ▸ | GSK3B | P49841 | 1/20 | 0.68 |
| ▸ | DYRK1A | Q13627 | 14/20 | 0.67 |
| ▸ | CCNA1 | P78396 | 13/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4559411 | 1.00 | CDK5 (0.74) | CDK5CDK5R1KDM4EMAPTNPC1 | |
| SCHEMBL4490485 | 0.89 | CDK5 (0.73) | CDK5CDK5R1KDM4EMAPTCDK2 | |
| SCHEMBL4490493 | 0.89 | CDK5 (0.73) | CDK5CDK5R1KDM4EMAPTCDK2 | |
| SCHEMBL28453366 | 0.85 | CDK5 (0.80) | CDK5CDK5R1KDM4EMAPTNPC1 | |
| SCHEMBL28453367 | 0.85 | CDK5 (0.80) | CDK5CDK5R1KDM4EMAPTNPC1 | |
| SCHEMBL22651813 | 0.85 | CDK5 (0.83) | CDK5CDK5R1KDM4EMAPTNPC1 | |
| SCHEMBL13638194 | 0.84 | CDK5 (0.76) | CDK5CDK5R1KDM4EMAPTNPC1 | |
| SCHEMBL20792022 | 0.81 | CDK5 (1.00) | CDK5CDK5R1KDM4EMAPTNPC1 | |
| SCHEMBL29435003 | 0.81 | CDK5 (1.00) | CDK5CDK5R1KDM4EMAPTNPC1 | |
| Hydrochloric Acid SCHEMBL29562722 | 0.80 | CDK5 (0.98) | CDK5CDK5R1KDM4EMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612079-B2 | 2,6,9-substituted purine derivatives and their use in the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| EP-1399446-B1 | 2,6,9-SUBSTITUTED PURINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | CYCLACEL LTD (GB) | 2005-08-03 | — | — | EP | disclosed |
| US-20050009846-A1 | 2,6,9-Substituted purine derivatives and their use in the treatment of proliferative disorders | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009846-A1 | 2,6,9-Substituted purine derivatives and their use in the treatment of proliferative disorders | TYMP, PNP, IMPDH1 | CDK5 83/4885CDK5R1 107/4885KDM4E 989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.