Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3549290 | 0.93 | SMN1; SMN2 (0.47) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL3546489 | 0.86 | SMN1; SMN2 (0.52) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL5760900 | 0.84 | SMN1; SMN2 (0.46) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL3547836 | 0.84 | SMN1; SMN2 (0.46) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL3551575 | 0.83 | SMN1; SMN2 (0.49) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL3540398 | 0.83 | SMN1; SMN2 (0.47) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL3554548 | 0.82 | SMN1; SMN2 (0.49) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL5246847 | 0.82 | TP53 (0.56) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL3548397 | 0.82 | SMN1; SMN2 (0.47) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL5759970 | 0.82 | SMN1; SMN2 (0.47) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306156-A1 | PHOSPHODIESTERASE 4 INHIBITORS | HOPPER ALLEN | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306156-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE3B, PDE5A | PDE4A 1/4885PDE4B 5/4885PDE4C 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.