Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 8/20 | 0.62 |
| ▸ | JAK2 | O60674 | 7/20 | 0.62 |
| ▸ | TYK2 | P29597 | 6/20 | 0.61 |
| ▸ | JAK3 | P52333 | 5/20 | 0.61 |
| ▸ | CDK19 | Q9BWU1 | 4/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.58 |
| ▸ | STAT3 | P40763 | 2/20 | 0.52 |
| ▸ | IGF1R | P08069 | 4/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30891585 | 0.84 | JAK1 (0.65) | JAK1JAK2TYK2JAK3CDK19 | |
| SCHEMBL30956572 | 0.83 | JAK1 (0.58) | JAK1JAK2TYK2JAK3ALK | |
| SCHEMBL4560068 | 0.81 | JAK1 (0.58) | JAK1JAK2TYK2JAK3CDK19 | |
| SCHEMBL4561905 | 0.81 | JAK2 (0.64) | JAK1JAK2TYK2JAK3CDK19 | |
| SCHEMBL30956586 | 0.80 | JAK1 (0.60) | JAK1JAK2TYK2JAK3CDK19 | |
| SCHEMBL4561835 | 0.79 | IGF1R (0.61) | JAK1JAK2TYK2JAK3CDK19 | |
| SCHEMBL18410177 | 0.79 | JAK1 (0.61) | JAK1JAK2TYK2JAK3CDK19 | |
| SCHEMBL5022297 | 0.79 | JAK1 (0.61) | JAK1JAK2TYK2JAK3CDK19 | |
| SCHEMBL4561923 | 0.78 | JAK1 (0.53) | JAK1JAK2TYK2JAK3CDK19 | |
| SCHEMBL4561655 | 0.78 | JAK1 (0.52) | JAK1JAK2TYK2JAK3CDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638018-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-09-18 | — | — | EP | claimed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | claimed |
| EP-2638018-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |