Sugi Predict

Sugi Predict / Compounds / SCHEMBL4559700

SCHEMBL4559700

SCHEMBL4559700

C=CC[C@H](C(N)=O)[C@@H](CC1CCC1)C(=O)NC1CN(c2ccccc2)c2ccccc2N(c2cccc(C(=O)c3ccccc3)c2)C1=O

nearest known ligand 0.35

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ NOTCH1 P46531 2/20 0.35
▸ RBPJ Q06330 2/20 0.35
▸ MME P08473 1/20 0.33
▸ ACE P12821 1/20 0.33
▸ APP P05067 2/20 0.33
▸ CCKBR P32239 1/20 0.32
▸ KMT2A Q03164 2/20 0.31
▸ POLB P06746 1/20 0.31
▸ MEN1 O00255 1/20 0.31
▸ OPRM1 P35372 1/20 0.30
▸ OPRL1 P41146 1/20 0.30
▸ ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4558872 0.98 MME (0.35) NOTCH1RBPJMMEACEAPP
SCHEMBL4558882 0.97 NOTCH1 (0.35) NOTCH1RBPJMMEACEAPP
SCHEMBL4559719 0.90 APP (0.41) NOTCH1RBPJAPPCCKBR
SCHEMBL4559004 0.89 APP (0.38) NOTCH1RBPJMMEACEAPP
SCHEMBL5665900 0.89 APP (0.43) NOTCH1RBPJAPPCCKBR
SCHEMBL4559181 0.87 APP (0.39) NOTCH1RBPJMMEACEAPP
SCHEMBL4557537 0.87 APP (0.41) NOTCH1RBPJAPP
SCHEMBL4559750 0.86 APP (0.37) NOTCH1RBPJMMEACEAPP
SCHEMBL4559113 0.83 APP (0.40) NOTCH1RBPJMMEACEAPP
SCHEMBL4558886 0.83 PSEN1 (0.41) NOTCH1RBPJCCKBR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030134841-A1 Succinoylamino lactams as inhibitors of A-beta protein production OLSON RICHARD E (US) 2003-07-17 — — US claimed
US-7507815-B2 Succinoylamino lactams as inhibitors of a-β protein production BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2009-03-24 — — US disclosed
US-20080293692-A1 SUCCINOYLAMINO LACTAMS AS INHIBITORS OF A-BETA PROTEIN PRODUCTION BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2008-11-27 — — US disclosed
US-7101870-B2 Succinoylamino lactams as inhibitors of A-β protein production BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2006-09-05 — — US disclosed
US-6962913-B2 Benzo-1,4-diazepin-2-ones as inhibitors of Aβ protein production BRISTOL-MYERS SQUIBB COMPANY (US) 2005-11-08 — — US disclosed
US-6794381-B1 BETA -PEPTIDE INHIBITOR PREVENTS NEUROLOGICAL DEPOSITS OF AMYLOID PRECURSOR PROTEIN; ALZHEIMER'S DISEASE AND DOWN'S SYNDROME TREATMENT BRISTOL-MYERS SQUIBB COMPANY 2004-09-21 — — US disclosed
US-20030134841-A1 Succinoylamino lactams as inhibitors of A-beta protein production OLSON RICHARD E (US) 2003-07-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080293692-A1 SUCCINOYLAMINO LACTAMS AS INHIBITORS OF A-BETA PROTEIN PRODUCTION BACE1, APH1A, APP NOTCH1 94/4885RBPJ 1902/4885MME 956/4885
US-20030134841-A1 Succinoylamino lactams as inhibitors of A-beta protein production APH1A, BACE1, APP NOTCH1 125/4885RBPJ 1850/4885MME 824/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.