Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.74 |
| ▸ | GSK3B | P49841 | 11/20 | 0.67 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4488169 | 0.82 | GSK3B (0.82) | DYRK1AGSK3B | |
| SCHEMBL4486472 | 0.82 | DYRK1A (0.76) | DYRK1AGSK3BPDPK1JAK2IDO1 | |
| SCHEMBL31061530 | 0.81 | GSK3B (1.00) | DYRK1AGSK3B | |
| SCHEMBL6490286 | 0.81 | GSK3B (1.00) | DYRK1AGSK3B | |
| SCHEMBL2261204 | 0.80 | DYRK1A (0.65) | DYRK1AGSK3BPDPK1JAK2IDO1 | |
| SCHEMBL15484452 | 0.80 | DYRK1A (0.69) | DYRK1AGSK3BPDPK1JAK2IDO1 | |
| SCHEMBL6478928 | 0.80 | DYRK1A (0.69) | DYRK1AGSK3BPDPK1JAK2IDO1 | |
| SCHEMBL6478923 | 0.80 | DYRK1A (0.69) | DYRK1AGSK3BPDPK1JAK2IDO1 | |
| SCHEMBL17848098 | 0.79 | DYRK1A (0.85) | DYRK1AGSK3BPDPK1JAK2IDO1 | |
| SCHEMBL17859180 | 0.79 | GSK3B (0.74) | DYRK1AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2637660-A1 | FATTY ACID SYNTHASE INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012064642-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-05-18 | — | — | WO | disclosed |