Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 19/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | LATS1 | O95835 | 1/20 | 0.37 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4379557 | 0.97 | GSK3B (0.43) | GSK3BCYP2D6LATS1LATS2 | |
| SCHEMBL4385249 | 0.85 | GSK3B (0.46) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL4380836 | 0.82 | GSK3B (0.46) | GSK3BCYP2D6CYP1A2LATS1LATS2 | |
| SCHEMBL15512999 | 0.80 | GSK3B (0.44) | GSK3BCYP2D6LATS1LATS2 | |
| SCHEMBL1832408 | 0.71 | GSK3B (0.42) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL1833092 | 0.70 | GSK3B (0.47) | GSK3BCYP2D6 | |
| SCHEMBL4377775 | 0.70 | GSK3B (0.39) | GSK3BCYP2D6CYP1A2LATS1LATS2 | |
| SCHEMBL1830258 | 0.70 | GSK3B (0.49) | GSK3BCYP2D6 | |
| SCHEMBL1833018 | 0.69 | GSK3B (0.48) | GSK3BCYP2D6 | |
| SCHEMBL3568709 | 0.69 | GSK3B (0.48) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121635-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008078196-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | disclosed |