Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 12/20 | 0.58 |
| ▸ | JAK1 | P23458 | 10/20 | 0.58 |
| ▸ | TYK2 | P29597 | 6/20 | 0.58 |
| ▸ | JAK2 | O60674 | 7/20 | 0.54 |
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.49 |
| ▸ | CDC7 | O00311 | 2/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | PAK4 | O96013 | 2/20 | 0.49 |
| ▸ | PIM1 | P11309 | 2/20 | 0.49 |
| ▸ | PRKACA | P17612 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.49 |
| ▸ | CLK2 | P49760 | 2/20 | 0.49 |
| ▸ | GSK3A | P49840 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30956453 | 0.91 | JAK1 (0.50) | JAK3JAK1TYK2JAK2KDR | |
| SCHEMBL22097802 | 0.91 | JAK1 (0.50) | JAK3JAK1TYK2JAK2KDR | |
| SCHEMBL24853225 | 0.89 | JAK1 (0.50) | JAK3JAK1TYK2JAK2KDR | |
| SCHEMBL4562044 | 0.88 | JAK1 (0.48) | JAK3JAK1TYK2JAK2KDR | |
| SCHEMBL4562740 | 0.85 | JAK1 (0.55) | JAK3JAK1TYK2JAK2KDR | |
| SCHEMBL4562127 | 0.85 | JAK1 (0.55) | JAK3JAK1TYK2JAK2KDR | |
| SCHEMBL29941695 | 0.85 | JAK2 (0.55) | JAK3JAK1TYK2JAK2KDR | |
| SCHEMBL22097794 | 0.85 | JAK2 (0.55) | JAK3JAK1TYK2JAK2KDR | |
| SCHEMBL4561131 | 0.85 | JAK1 (0.53) | JAK3JAK1TYK2JAK2KDR | |
| SCHEMBL4562360 | 0.85 | JAK3 (0.51) | JAK3JAK1TYK2JAK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638018-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-09-18 | — | — | EP | claimed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | claimed |
| EP-2638018-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |