Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.54 |
| ▸ | JAK2 | O60674 | 6/20 | 0.50 |
| ▸ | JAK1 | P23458 | 5/20 | 0.50 |
| ▸ | TYK2 | P29597 | 3/20 | 0.50 |
| ▸ | JAK3 | P52333 | 3/20 | 0.50 |
| ▸ | STAT3 | P40763 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4561261 | 0.96 | JAK1 (0.51) | BRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL4559673 | 0.96 | JAK1 (0.53) | BRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL22098047 | 0.91 | JAK1 (0.47) | BRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL4559697 | 0.90 | JAK2 (0.52) | BRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL24853548 | 0.88 | JAK1 (0.51) | BRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL24853465 | 0.88 | JAK1 (0.51) | BRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL4562807 | 0.88 | JAK2 (0.53) | JAK2JAK1TYK2JAK3STAT3 | |
| SCHEMBL22097741 | 0.85 | JAK2 (0.54) | JAK2JAK1TYK2JAK3STAT3 | |
| SCHEMBL4560217 | 0.85 | JAK2 (0.52) | JAK2JAK1TYK2JAK3STAT3 | |
| SCHEMBL4561996 | 0.85 | JAK2 (0.52) | JAK2JAK1TYK2JAK3STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638018-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-09-18 | — | — | EP | claimed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | claimed |
| EP-2638018-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |