Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 13/20 | 0.44 |
| ▸ | AKT1 | P31749 | 11/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.44 |
| ▸ | AKT2 | P31751 | 6/20 | 0.44 |
| ▸ | AKT3 | Q9Y243 | 6/20 | 0.44 |
| ▸ | RPS6KA1 | Q15418 | 4/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | MARK3 | P27448 | 1/20 | 0.38 |
| ▸ | GRK5 | P34947 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065700 | 0.91 | RPS6KA5 (0.44) | RPS6KA5AKT1ROCK1AKT2AKT3 | |
| SCHEMBL4065048 | 0.84 | RPS6KA5 (0.47) | RPS6KA5AKT1ROCK1AKT2AKT3 | |
| SCHEMBL4065691 | 0.81 | AKT1 (0.61) | RPS6KA5AKT1ROCK1AKT2AKT3 | |
| SCHEMBL4061112 | 0.80 | RPS6KA5 (0.57) | RPS6KA5AKT1ROCK1AKT2AKT3 | |
| SCHEMBL4065033 | 0.79 | RPS6KA5 (0.48) | RPS6KA5AKT1ROCK1AKT2AKT3 | |
| SCHEMBL4073423 | 0.78 | SLC2A1 (0.47) | RPS6KA5AKT1ROCK1AKT2AKT3 | |
| SCHEMBL4070054 | 0.78 | RPS6KA5 (0.47) | RPS6KA5AKT1ROCK1AKT2AKT3 | |
| Trifluoroacetic Acid SCHEMBL5063621 | 0.77 | AKT1 (0.56) | RPS6KA5AKT1ROCK1AKT2AKT3 | |
| SCHEMBL4071929 | 0.77 | RPS6KA5 (0.55) | RPS6KA5AKT1ROCK1AKT2AKT3 | |
| SCHEMBL4237181 | 0.76 | SLC2A1 (0.48) | RPS6KA5AKT1ROCK1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1653961-A4 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORP (US) | 2009-04-01 | — | — | EP | claimed |
| EP-1653961-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | claimed |
| WO-2005011700-A1 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-10 | — | — | WO | claimed |