Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 17/20 | 0.62 |
| ▸ | LCK | P06239 | 2/20 | 0.62 |
| ▸ | KDR | P35968 | 1/20 | 0.62 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | STK10 | O94804 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | YES1 | P07947 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | HCK | P08631 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.51 |
| ▸ | PRKCA | P17252 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6099658 | 0.85 | EGFR (0.61) | EGFRERBB2LCKKDRAAK1 | |
| SCHEMBL1220394 | 0.80 | EGFR (0.71) | EGFRERBB2LCKKDRAAK1 | |
| SCHEMBL1220440 | 0.80 | EGFR (0.71) | EGFRERBB2LCKKDRAAK1 | |
| SCHEMBL1220396 | 0.80 | EGFR (0.71) | EGFRERBB2LCKKDRAAK1 | |
| SCHEMBL1218828 | 0.79 | EGFR (0.84) | EGFRERBB2LCKKDRAAK1 | |
| SCHEMBL3553531 | 0.77 | EGFR (0.81) | EGFRERBB2LCKKDRAAK1 | |
| SCHEMBL3554356 | 0.77 | EGFR (0.71) | EGFRERBB2LCKKDRAAK1 | |
| SCHEMBL1219457 | 0.77 | EGFR (1.00) | EGFRERBB2LCKKDRAAK1 | |
| SCHEMBL1220093 | 0.77 | EGFR (0.83) | EGFRERBB2LCKKDRAAK1 | |
| SCHEMBL1220849 | 0.76 | EGFR (1.00) | EGFRERBB2LCKKDRAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699798-A4 | DI-SUBSTITUTED PYRROLOTRIAZINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2009-03-11 | — | — | EP | disclosed |
| EP-1699798-A2 | DI-SUBSTITUTED PYRROLOTRIAZINE COMPOUNDS | Bristol-Myers Squibb Company (US) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005065266-A2 | DI-SUBSTITUTED PYRROLOTRIAZINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-07-21 | — | — | WO | disclosed |