Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.82 |
| ▸ | RAF1 | P04049 | 9/20 | 0.82 |
| ▸ | KDR | P35968 | 4/20 | 0.82 |
| ▸ | LCK | P06239 | 3/20 | 0.82 |
| ▸ | FYN | P06241 | 3/20 | 0.82 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.82 |
| ▸ | KIT | P10721 | 3/20 | 0.82 |
| ▸ | FLT1 | P17948 | 3/20 | 0.82 |
| ▸ | FLT4 | P35916 | 3/20 | 0.82 |
| ▸ | STK25 | O00506 | 1/20 | 0.82 |
| ▸ | CIT | O14578 | 1/20 | 0.82 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.82 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.82 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.82 |
| ▸ | PAK3 | O75914 | 1/20 | 0.82 |
| ▸ | STK10 | O94804 | 1/20 | 0.82 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.82 |
| ▸ | ABL1 | P00519 | 1/20 | 0.82 |
| ▸ | CSF1R | P07333 | 1/20 | 0.82 |
| ▸ | YES1 | P07947 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1435201 | 0.93 | BRAF (0.83) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL11996499 | 0.90 | BRAF (0.87) | BRAFRAF1KDRLCKFYN | |
| Raf-265 SCHEMBL29355586 | 0.90 | BRAF (1.00) | BRAFRAF1KDRLCKFYN | |
| Raf-265 SCHEMBL1562237 | 0.90 | BRAF (1.00) | BRAFRAF1KDRLCKFYN | |
| Raf-265 SCHEMBL29368571 | 0.90 | BRAF (1.00) | BRAFRAF1KDRLCKFYN | |
| Raf-265 SCHEMBL686452 | 0.90 | BRAF (1.00) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL681128 | 0.90 | BRAF (0.87) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL1435161 | 0.89 | BRAF (0.86) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL12811765 | 0.89 | BRAF (0.86) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL1435427 | 0.89 | BRAF (0.86) | BRAFRAF1KDRLCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3941462-A1 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | Achillion Pharmaceuticals, Inc. (US) | 2022-01-26 | — | — | EP | disclosed |
| EP-2132198-A1 | SOLID FORMS OF A RAF KINASE INHIBITOR | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008140850-A1 | SOLID FORMS OF A RAF KINASE INHIBITOR | NOVARTIS AG (CH) | 2008-11-20 | — | — | WO | disclosed |