Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.85 |
| ▸ | MTOR | P42345 | 20/20 | 0.85 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.65 |
| ▸ | ATR | Q13535 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4562698 | 0.97 | PIK3CA (0.85) | PIK3CAMTORPIK3CGATR | |
| SCHEMBL4562940 | 0.96 | PIK3CA (0.84) | PIK3CAMTORPIK3CGATR | |
| SCHEMBL3994356 | 0.96 | PIK3CA (0.87) | PIK3CAMTORPIK3CGATR | |
| SCHEMBL4563300 | 0.95 | PIK3CA (0.78) | PIK3CAMTORPIK3CGATR | |
| SCHEMBL4997859 | 0.92 | PIK3CA (1.00) | PIK3CAMTORPIK3CGATR | |
| SCHEMBL3991734 | 0.91 | PIK3CA (0.84) | PIK3CAMTORPIK3CGATR | |
| SCHEMBL3987199 | 0.89 | PIK3CA (1.00) | PIK3CAMTORPIK3CGATR | |
| SCHEMBL4996622 | 0.89 | PIK3CA (1.00) | PIK3CAMTORPIK3CGATR | |
| SCHEMBL4989715 | 0.89 | PIK3CA (0.99) | PIK3CAMTORPIK3CGATR | |
| SCHEMBL3983804 | 0.88 | PIK3CA (0.75) | PIK3CAMTORPIK3CGATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078021-A2 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-07-15 | — | — | EP | claimed |
| WO-2008115974-A2 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | WYETH (US) | 2008-09-25 | — | — | WO | claimed |