Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.80 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.56 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.56 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.56 |
| ▸ | TNF | P01375 | 4/20 | 0.56 |
| ▸ | CIT | O14578 | 1/20 | 0.56 |
| ▸ | MUSK | O15146 | 1/20 | 0.56 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | STK10 | O94804 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.56 |
| ▸ | PRKCB | P05771 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1600485 | 0.89 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11TNF | |
| SCHEMBL6167223 | 0.83 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11TNF | |
| SCHEMBL1600552 | 0.83 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11TNF | |
| SCHEMBL1599846 | 0.80 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11TNF | |
| SCHEMBL1599504 | 0.80 | MAPK14 (0.82) | MAPK14MAPK13MAPK12MAPK11TNF | |
| SCHEMBL5255198 | 0.79 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11TNF | |
| SCHEMBL1599825 | 0.78 | DDR2 (0.72) | MAPK14MAPK13MAPK12MAPK11TNF | |
| SCHEMBL13234437 | 0.78 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11TNF | |
| SCHEMBL1599371 | 0.78 | MAPK14 (0.80) | MAPK14MAPK13MAPK12MAPK11TNF | |
| SCHEMBL30449051 | 0.78 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006091862-A2 | CYTOKINE INHIBITORS AND THEIR USE IN THERAPY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | claimed |
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2006091862-A2 | CYTOKINE INHIBITORS AND THEIR USE IN THERAPY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | disclosed |