Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.40 |
| ▸ | RAF1 | P04049 | 4/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | KRAS | P01116 | 2/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4279129 | 0.85 | BRAF (0.41) | BRAFRAF1KDRKRASMAP2K2 | |
| SCHEMBL4277292 | 0.83 | BRAF (0.40) | BRAFRAF1KDRKRASMAP2K2 | |
| SCHEMBL4276053 | 0.82 | BRAF (0.39) | BRAFRAF1KDRKRASMAP2K2 | |
| SCHEMBL5067060 | 0.65 | BRAF (0.54) | BRAFRAF1KDRKRASMAP2K2 | |
| SCHEMBL4275951 | 0.64 | BRAF (0.60) | BRAFRAF1KDRKRASMAP2K2 | |
| SCHEMBL1521542 | 0.64 | TNK2 (0.49) | BRAFRAF1KDRKRASMAP2K2 | |
| SCHEMBL5061877 | 0.64 | BRAF (0.56) | BRAFRAF1KDRKRASMAP2K2 | |
| SCHEMBL1521549 | 0.64 | BRAF (0.43) | BRAFRAF1KDRKRASMAP2K2 | |
| SCHEMBL1521733 | 0.63 | ABL1 (0.45) | BRAFRAF1KDRKRASMAP2K2 | |
| SCHEMBL5067066 | 0.63 | BRAF (0.52) | BRAFRAF1KDRKRASMAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063896-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008033999-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-03-20 | — | — | WO | disclosed |